MRC Clinical Practitioner
- Employer
- St George's Healthcare NHS Foundation Trust
- Location
- London
- Salary
- £51,488 to £65,095 a year pa pro rata
- Closing date
- 4 Aug 2024
View more
- Profession
- Other Health Profession
- Grade
- Band 7
- Hours
- Full Time
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MRC Clinical Practitioner
Band 7 - 8A Depending upon previous experience and skills.
The postholder will be involved in a programme of research funded by the Medical Research Council (MRC) and the British Heart Foundation (BHF) where they will be responsible for the co-ordination and management of the clinical research studies.
The overall purpose of the grant is to investigate, in much greater depth and using state of the art techniques, patients with known categories (phenotypes) of primary lymphoedema. Many of these patients will already have been given a genetic diagnosis (genotype). The aim is to understand better how the lymph system goes wrong with each category of lymphoedema in the hope that this will ultimately lead to new treatments. The post holder will be responsible for assisting the clinicians in the Primary Lymphoedema Clinic in recruiting suitable patients to the research study. They will assist with updating the regulatory approvals as necessary, identify from our database of over 1000 patients who might be suitable for recruitment, and then coordinate that recruitment based on phenotypes required for each study and the practicalities and logistics e.g. ease of travel of participant attendance. Participants will be entered into observational studies including ICG lymphography, MR lymphangiography, skin biopsies, and immune profiling.
Main duties of the job
Work closely with the Principal Investigators in ensuring the successful working of the project.
Co-ordinate and manage the clinical research within theLymphovascular Research Team and ensure that the team works within Good Clinical Practice guidelines and ethical standards.
Maintain and adhere to Standard Operating Procedures for all aspects of clinical research activities to comply with ICH/GCP (International Conference for Harmonisation/Good Clinical Practice) for the EU Clinical Trial Directive
About us
Over the last 20 years, the clinical interdisciplinary team at St George's led by Prof Mortimer, Prof Mansour, and Dr Gordon, has built up an unrivalled expertise in the phenotyping of primary lymphoedema. Better diagnostic criteria and patient grouping has enabled our team to develop a new internationally accepted clinical pathway/algorithm for the classification of lymphoedema based on phenotype.
Deeper phenotyping through detailed investigation is required however, and this study will play an important role in providing data to complement this process. A multidimensional approach is being employed by St George's, using data from MRL, ICG lymphography and lymphoscintigraphy to study lymph vessel macromorphology 3D ultramicroscopy to study individual lymph vessels immune profiling to study the immune defects and clinical insights. The successful applicant will play a crucial role in recruiting patients with primary lymphoedema from the clinic to the research studies, in undertaking investigative procedures, and in updating the research database.
Job description
Job responsibilities
The postholder will be involved in a programme of research funded by the Medical Research Council (MRC) and the British Heart Foundation (BHF) where they will be responsible for the co-ordination and management of the clinical research studies.
The overall purpose of the grant is to investigate, in much greater depth and using state of the art techniques, patients with known categories (phenotypes) of primary lymphoedema. Many of these patients will already have been given a genetic diagnosis (genotype). The aim is to understand better how the lymph system goes wrong with each category of lymphoedema in the hope that this will ultimately lead to new treatments. The post holder will be responsible for assisting the clinicians in the Primary Lymphoedema Clinic in recruiting suitable patients to the research study. They will assist with updating the regulatory approvals as necessary, identify from our database of over 1000 patients who might be suitable for recruitment, and then coordinate that recruitment based on phenotypes required for each study and the practicalities and logistics e.g. ease of travel of participant attendance. Participants will be entered into observational studies including ICG lymphography, MR lymphangiography, skin biopsies, and immune profiling.
In addition, it is essential that the post holder can take blood samples, administer local anaesthetic injections, and give intradermal injections of imaging tracers (such as indocyanine green for ICG Lymphography and gadolinium for MR lymphangiography). It is desirable that they can perform small skin punch biopsies (training can be provided in-post) and conduct ICG lymphography (giving intradermal injections and using imaging camera), but this can be taught once in post.
The postholder will be expected to be able to work autonomously, yet jointly with other members of the research team. For more details see summary of Person Specifications further down.
********For full Person Specification please see attached JD*********
Person Specification
Experience
Essential
Desirable
Paediatric Lypmhoedema experience
Essential
Desirable
Employer details
Employer name
St George's Healthcare NHS Foundation Trust
Address
St Georges University Hospital
London
SW17 0QT
Any attachments will be accessible after you click to apply.
200-6319643-MA-SC
Band 7 - 8A Depending upon previous experience and skills.
The postholder will be involved in a programme of research funded by the Medical Research Council (MRC) and the British Heart Foundation (BHF) where they will be responsible for the co-ordination and management of the clinical research studies.
The overall purpose of the grant is to investigate, in much greater depth and using state of the art techniques, patients with known categories (phenotypes) of primary lymphoedema. Many of these patients will already have been given a genetic diagnosis (genotype). The aim is to understand better how the lymph system goes wrong with each category of lymphoedema in the hope that this will ultimately lead to new treatments. The post holder will be responsible for assisting the clinicians in the Primary Lymphoedema Clinic in recruiting suitable patients to the research study. They will assist with updating the regulatory approvals as necessary, identify from our database of over 1000 patients who might be suitable for recruitment, and then coordinate that recruitment based on phenotypes required for each study and the practicalities and logistics e.g. ease of travel of participant attendance. Participants will be entered into observational studies including ICG lymphography, MR lymphangiography, skin biopsies, and immune profiling.
Main duties of the job
Work closely with the Principal Investigators in ensuring the successful working of the project.
Co-ordinate and manage the clinical research within theLymphovascular Research Team and ensure that the team works within Good Clinical Practice guidelines and ethical standards.
Maintain and adhere to Standard Operating Procedures for all aspects of clinical research activities to comply with ICH/GCP (International Conference for Harmonisation/Good Clinical Practice) for the EU Clinical Trial Directive
About us
Over the last 20 years, the clinical interdisciplinary team at St George's led by Prof Mortimer, Prof Mansour, and Dr Gordon, has built up an unrivalled expertise in the phenotyping of primary lymphoedema. Better diagnostic criteria and patient grouping has enabled our team to develop a new internationally accepted clinical pathway/algorithm for the classification of lymphoedema based on phenotype.
Deeper phenotyping through detailed investigation is required however, and this study will play an important role in providing data to complement this process. A multidimensional approach is being employed by St George's, using data from MRL, ICG lymphography and lymphoscintigraphy to study lymph vessel macromorphology 3D ultramicroscopy to study individual lymph vessels immune profiling to study the immune defects and clinical insights. The successful applicant will play a crucial role in recruiting patients with primary lymphoedema from the clinic to the research studies, in undertaking investigative procedures, and in updating the research database.
Job description
Job responsibilities
The postholder will be involved in a programme of research funded by the Medical Research Council (MRC) and the British Heart Foundation (BHF) where they will be responsible for the co-ordination and management of the clinical research studies.
The overall purpose of the grant is to investigate, in much greater depth and using state of the art techniques, patients with known categories (phenotypes) of primary lymphoedema. Many of these patients will already have been given a genetic diagnosis (genotype). The aim is to understand better how the lymph system goes wrong with each category of lymphoedema in the hope that this will ultimately lead to new treatments. The post holder will be responsible for assisting the clinicians in the Primary Lymphoedema Clinic in recruiting suitable patients to the research study. They will assist with updating the regulatory approvals as necessary, identify from our database of over 1000 patients who might be suitable for recruitment, and then coordinate that recruitment based on phenotypes required for each study and the practicalities and logistics e.g. ease of travel of participant attendance. Participants will be entered into observational studies including ICG lymphography, MR lymphangiography, skin biopsies, and immune profiling.
In addition, it is essential that the post holder can take blood samples, administer local anaesthetic injections, and give intradermal injections of imaging tracers (such as indocyanine green for ICG Lymphography and gadolinium for MR lymphangiography). It is desirable that they can perform small skin punch biopsies (training can be provided in-post) and conduct ICG lymphography (giving intradermal injections and using imaging camera), but this can be taught once in post.
The postholder will be expected to be able to work autonomously, yet jointly with other members of the research team. For more details see summary of Person Specifications further down.
********For full Person Specification please see attached JD*********
Person Specification
Experience
Essential
- Experience working with Lymphoedema
Desirable
- Experience working with Lymphoedema
Paediatric Lypmhoedema experience
Essential
- Practical Lymphoedema Paediatric and Adult Clinical Experience
Desirable
- Practical Lymphoedema Paediatric and Adult Clinical Experience
Employer details
Employer name
St George's Healthcare NHS Foundation Trust
Address
St Georges University Hospital
London
SW17 0QT
Any attachments will be accessible after you click to apply.
200-6319643-MA-SC
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