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Clinical Research Fellow in Neurology

University Hospital Southampton NHS Foundation Trust
£43,923 Per Annum
Closing date
26 Nov 2023

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We are looking for an enthusiastic and self-motivated Clinical Research Fellow. This post is an exciting opportunity for a clinical trainee seeking to advance their research career, further develop their academic interest in multiple sclerosis (MS) and enhance their publication profile.

The post-holder will work with clinicians and laboratory-based scientists in a distinguished neuroscience research team, studying MS and other neurological conditions. Research benefits from deep ties with the Research and Development department at the University Hospital Southampton NHS Foundation Trust for clinical research delivery, a wet laboratory with biochemical, molecular and histochemical capability, image-processing workstations, and access to high-performance supercomputing, a research-dedicated MRI scanner, and other facilities. The post-holder can benefit from the Southampton Academy of Research (SOAR), to gain the necessary skills to develop their own high-quality research activity.

Main duties of the job

Attached you will find the person specification document which provides more detail about the essential and desirable skills and experience needed for this role. We highly recommend you review this document and use it when completing your application as these criteria are used by hiring managers as guidance during shortlisting.

For an overview of the main duties of the role please see the 'Job Description and Main Responsibilities' section below. To understand the day-to-day responsibilities in more detail please read the full job description document attached.

About us

As one of the largest acute teaching Trusts in England, we offer learning and development opportunities to help you achieve the career you aspire to. UHS is rated 'Good' by the CQC and in the latest national NHS Staff Survey, we were in the top 10 acute trusts for staff engagement and for staff recommending the hospital as a place to work or receive care.

We support flexible working and will consider requests taking into account the needs of the service. UHS employees are able to access a range of NHS discounts, are entitled to a minimum of 35 days paid holiday (pro rata), and we offer a generous pension scheme.

Southampton is an attractive place to live and work situated on the south coast, with an international airport and direct trains to London. The New Forest National Park and beaches of the Jurassic coast are also right on our doorstep. The city offers living costs 20% lower than London and 14 schools rated outstanding by Ofsted.

Job description

Job responsibilities


The Fellow will conduct a leading research role in three areas:
  • The OCTOPUS trial, which is a multi-arm, multi-stage (MAMS) randomized controlled trial in progressive MS, initially comparing alpha-lipoic acid and metformin versus placebo.
  • The role of haemolysis in driving progression in MS.
  • Validation and testing the clinical deployment of a cerebrospinal fluid light chain assay as an alternative to isoelectric focusing in the diagnosis and management of MS.

  • Within the OCTOPUS trail, the fellow will recruit and follow-up patients, including screening, baseline visits, supervision of MR imaging and blinded assessments during follow-up. The fellow will engage with other centres in the region, help integrate trial activity across between research and clinical settings, and act as an OCTOPUS and Stop MS Appeal ambassador to drive publicity of trial and donor events in liaison with the MS Society.

    The post-holder will be based on the University of Southampton and have an honorary appointment with the University Hospital Southampton NHS Foundation Trust. They will be offered the opportunity to attend MS outpatient clinics and multidisciplinary team meetings, working under varying degrees of supervision depending on experience. There will be an emphasis on the post-holders clinical research career development, for example designing ones own research ideas, gathering preliminary data, and/or preparing a fellowship funding application if this is a desired direction of travel.


    You will have a MBBS (Bachelor of Medicine & Bachelor of Surgery) degree or equivalent, experience working as a doctor, and Advanced Life Support certification. Essential to this post is high proficiency in intravenous cannulation and the ability to drive ones own car to attend satellite clinics (for example in Bournemouth and Warminster). The MRCP degree (in part or full), previous neurology experience, postgraduate research degrees, participation in clinical trials and experience of using ultrasound for intravenous cannulation would be advantages but are not essential. The successful applicant will be highly motivated, capable of independent working and have excellent organisational and communication skills.


    Appointment will be made under local contractual terms and conditions of service for Trust appointed (non-training fellow doctors and dentists).

    Successful candidates will have an educational framework equivalent to training grade doctors, and there will be a named educational supervisor assigned at the start of the post. The opportunity for Continued Professional Development (CPD) is highly supported and encouraged by the Trust, with options available to take study leave. All licensed doctors must meet the GMC requirements for revalidation and there will be an annual appraisal to support this process.

    Grades for Trust appointed (non-training) fellows will be paid a basic salary at a nodal pay point linked to the grade, at the rate set out in the National Medical and Dental pay circular. Basic salary detailed below plus any additional remuneration (as applicable) for hours set out in the doctors work schedule (e.g. additional hours, weekend allowance, and any hours which attract enhanced pay)

    Basic Salary - MT03 �43,923

    This post is available part time (2.5 or 3 days a week) for one year with the possibility of extension, with a start date of 7th February 2024.

    Travelling expenses will not be paid for attending interview

    Please note that GMC registration (with a licence to practice) and right to work in the UK are essential for this role. Successful applicants will already have GMC registration or will be able to demonstrate they are eligible. Applicants requiring Tier 2 sponsorship should ensure they meet the Home Office application criteria prior to submitting an application.

    Interviews will be held on Wednesday, 06 December 2023

    Job Reference: MT1073 -MEDICAL

    This vacancy closes on or before: 25th November 2023

    Person Specification

    Qualifications and training


    • MBBS or equivalent medical qualification
    • GMC registration with a licence to practice
    • Advanced Life Support Certification


    • MRCP (Part 1 or full)
    • BSc / MSc / PhD
    • Good Clinical Practice certificate

    Aptitudes and skills


    • Evidence of participation in undergraduate and postgraduate teaching

    Previous or relevant experience


    • Appropriate knowledge base, and ability to apply sound clinical judgement to problems
    • Experience working in neurology
    • High proficiency with intravenous cannulation


    • Clinical trials experience
    • Teaching at undergraduate level and contributing to teaching at postgraduate level
    • Detailed understanding and experience in multiple sclerosis
    • Publications in peer-reviewed scientific journals
    • Ultrasound guidance for intravenous cannulation

    Aptitudes and skills


    • Demonstrate the ability to be calm, compassionate, and able to respond efficiently to various circumstances, which may change rapidly
    • Able to organise own research activities to deadline and quality standards
    • Able to develop understanding of complex problems and apply in-depth knowledge to address them
    • Able to develop original techniques/methods
    • Able to supervise work of junior research staff, delegating effectively
    • Work effectively in a team, understanding the strengths and weaknesses of others to help teamwork development
    • Communicate effectively and sympathetically with patients and their carers
    • Able to present research results at group meetings and conferences
    • Able to write up research results for publication in leading peer-viewed journals
    • Work proactively with colleagues in other work areas/institutions, contributing specialist knowledge to achieve outcomes
    • Understanding of relevant Health and Safety issues
    • Positive attitude to patients, colleagues and students

    Living the Trust values


    • Patients First
    • Always Improving
    • Working Together

    Aptitudes and skills


    • Evidence and ability to work effectively in multi-professional team
    • Understanding of equality and diversity and how this affects patients, visitors and staff
    • Evidence and ability to communicate and liaise effectively with patients and colleagues (verbal and written communication skills in English).
    • Demonstrate good organisational skills including ability to prioritise effectively and meet deadlines

    Employer details

    Employer name

    University Hospital Southampton NHS Trust


    NEU Med Staff Neurology


    SO16 6YD

    Any attachments will be accessible after you click to apply.


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