Weseek an ambitious, innovative individual with a specific interest in urology and early phase clinical trials to act as sub-investigator for a growing portfolio of complex clinical trials.
The role offers an exciting opportunity to work across 2 highly motivated & empowered teams to deliver innovative research. With consultant oversight, you will be responsible for seeing new referrals, follow-ups & managing the patient throughout all aspects of their trial experience. Within ECMT there is a regular molecular tumour board meeting supporting both local and national studies. You will take an active role in these meetings gaining valuable experience in using these data to identify and define suitable trial options for patients.
This is a 10 session non-training post. The position is suitable for individuals post-FY2 through to those having completed their specialist training in Oncology, and who wish to gain further experience in urology alongside experimental medicine and Phase I trials, including first-in-human trials, clinical pharmacology trials and translational research. You will work with a team of consultants, research nurses, clinical trials coordinators, translational research facilitators, secretarial support, rotating clinical fellows and specialty trainees. The post will have a focus on urology trials however the ECM team delivers trials in all major solid tumour types.Main duties of the job
The portfolio includes a diverse range of clinical research trials. Following training, you will be expected to participate in these studies as a sub-investigator. These include phase I trials of small molecule inhibitors, next-generation chemotherapy trials, combination / multi-modality phase I trials, molecular characterisation / translational studies, radiotherapy trials.
With a focus on urology studies, you will be involved in managing all aspects of trial patients (both in outpatient & in-patients setting), across a diverse range of solid tumours, through new patient consultation, consent & screening patients & reviewing patients at follow-up appointments.
You will be expected to attend safety review committee meetings to discuss trial patients. This will involve close liaison with the Principal Investigators. In addition, you will interface with external stakeholders such as CROs & pharmaceutical sponsors.
You will be expected to attend monthly molecular tumour board meetings to discuss trial patients and to agree opportunities for patients to enrol in early phase trials.
You will be expected to undertake the administrative duties associated with the care of our patients. You will be given opportunities and will be encouraged to be involved in the development & planning of new studies.
There is potential to present your research work & you will be expected to be involved in writing papers & reviews. You will also be required to undergo an annual appraisal.About us
The Christie is one of Europe's leading cancer centres, treating over 60,000 patients a year. We are based in Manchester and serve a population of 3.2 million across Greater Manchester & Cheshire, but as a national specialist around 15% patients are referred to us from other parts of the country. We provide radiotherapy through one of the largest radiotherapy departments in the world chemotherapy on site and through 14 other hospitals highly specialist surgery for complex and rare cancer and a wide range of support and diagnostic services. We are also an international leader in research, with world first breakthroughs for over 100 years. We run one of the largest early clinical trial units in Europe with over 300 trials every year. Cancer research in Manchester, most of which is undertaken on the Christie site, has been officially ranked the best in the UK.
The Experimental Cancer Medicine Team (ECMT) was established to facilitate early phase research, whilst the urology team deliver both early and late phase trials. You will be work across both teams, providing medical support to the consultants by primarily acting as sub-investigator on a range of clinical trials.Job descriptionJob responsibilities
The medical establishment provides 5 Consultant Medical Oncologists, and 3+ Senior/Clinical Fellows within the ECM team. In addition, the uro-oncology team provides 9 Consultant Clinical Oncologists, 2 specialty trainees, and 1-2 Clinical Fellows. DUTIES OF THE POST
- ROLE: The successful candidate will be recruited as a Clinical Fellow/Senior Clinical Fellow in the Experimental Cancer Medicine Team/Urology Research Team.
- RESEARCH: A diverse range of clinical research trials are in progress and, following training, the post holder will be expected to participate in these studies as a sub-investigator. These include late phase trials as well as phase I trials of small molecule inhibitors, next-generation chemotherapy trials, combination / multi-modality Phase I trials, molecular characterisation / translational studies
The post holder will be involved in managing all aspects of trial patients, with a focus (but not limited to) on urology patients, through new patient consultation, consent and screening patients and reviewing patients at follow-up appointments. Primarily, patients are seen in the outpatient setting but with some inpatient cover. The appointee is required to attend 4-5 trial outpatient clinics per week (see indicative timetable).
The post holder will be expected to attend Safety Review Committee meetings (usually remotely) to discuss trial patients. This will involve close liaison with the trial Principal Investigators, referring consultant body across the Trust and other members of the team. In addition, the post-holder will interface with external stakeholders such as CROs and pharmaceutical sponsors.
The post-holder will be expected to attend monthly molecular tumour board meetings to discuss trial patients and to agree opportunities for patients to enroll in early phase trials. PROTOCOLS:
The post holder will be expected to undertake the administrative duties associated with the care of their patients. The appointee will be encouraged to harness opportunities to be involved in the development and planning of new studies.
- Professional Development: The Clinical Fellow will maintain a level of continuing professional development consistent with the recommendations of the Royal College of Physicians. Appropriate arrangements for study leave will be made in conjunction with colleagues. There is the potential to present research work and the post holder will be expected to be involved in audit, writing papers and reviews. The post holder will also be required to undergo an annual appraisal
- Teaching Commitment:
The appointee will be required to contribute to the undergraduate teaching of medical students on oncology topics. b) Postgraduate
There is a busy postgraduate teaching programme and staff are often requested to lecture on relevant topics. The post holder will be expected to contribute actively to the education of junior doctors, specialty trainees and fellows on the team.
The post holder will also be expected to help in the training of nursing and multi-disciplinary staff in both in-patient and outpatient departments.
Continuing Professional Development
- Clinical Governance: The post holder will be expected to participate in all relevant aspects of clinical governance, including maintaining up to date protocols, guidelines and clinical audit, under the supervision of the other consultants in the team
- Audit: The appointee will play a full role in clinical audit as a member of The Christie Medical Staff Committee. The appointee will develop, supervise and deliver team audit projects.
The Trust supports the requirements for continuing professional development (CPD) as laid down by the GMC and surgical colleges and is committed to providing time and financial support for these activities. Role Planning
This is a 10 session non-training post (MN37) funded through The Christie NHS Foundation Trust for an initial period of 1 year. Provisional Sessional Timetable for Senior Clinical Fellow in Experimental Medicine ___________________________________________________________
Proposed Sessional Activities
Outpatient Clinics (split between Urology & ECMT) 5.0
Research Administration 2.0
Trial Teleconferences 0.5
Team Meeting 0.5
Audit/CPD 1.0 10 A Sessional Activity is 4 hours On call Commitments
This role does not require participation in the on-call rota. Contacts
Arrangements to visit the hospital or to discuss the role further, are encouraged and may be made direct with:
Dr Andrew Hudson
Dr Natalie Cook
email@example.com PERSON SPECIFICATION Essential for the post Desirable for the post METHOD OF ASSESSMENT 1. ATTAINMENTS Educational
Completion of foundation training or acute care
common Stem programme (or
CCT in Medical or Clinical Oncology or equivalent.
Good Clinical Practice.
Advanced Life Support.
Higher degree in cancer research
MRCP or equivalent Professional Qualifications
CE Research / Publications
Evidence of productive ethical research relevant to oncology
Recent publications in peer-reviewed journals.
R 2. TRAINING
Experience in general
oncology and internal
Experience in managing critically ill patients
R 3. EXPERIENCE Job Specific
Evidence of clinical leadership skills
Phase I trials experience
R Management / Audit
Experience of developing, supervising and delivering audit projects
R 4. TEACHING
Experience in teaching undergraduates
Experience in teaching postgraduates.Teaching Qualification
R Personal skills
Evidence of clinical skills.
Excellent written and oral communication skills, flexibility, commitment and team work with colleagues and staff in the department ability to work under pressure capacity for staff motivation
Demonstration of excellent communication skills
CE 5. CIRCUMSTANCES
Occupational Health ClearanceEnhanced CRB Clearance
CE Abbreviations for Methods of Assessment: AF Application Form I Interview R References CE Certification EvidencePerson SpecificationEducationalEssential
- Completion of foundation training or acute care common Stem programme (or equivalent)
QualificationsEssential Desirable Research/ PublicationsEssential
- CCT in Medical or Clinical Oncology or equivalent.
- Good Clinical Practice. Advanced Life Support.
- Higher degree in cancer research
- Evidence of productive ethical research relevant to oncology
- Recent publications in peer-reviewed journals. Conference presentations
- Experience in general oncology and internal medicine
- Research/Trials experience
- Experience in managing critically ill patients Any attachments will be accessible after you click to apply.